Bacterial Delivery Platform (BacID)

Active Intracellular Delivery

The BacID platform actively penetrates into the cancer cell cytosol, where it senses its environment and releases the therapeutic compounds directly where they are needed. This mechanisms bypasses the cell membrane barrier as well as endosomal release, two major obstacles in drug delivery.

In Situ Drug Production

The BacID platform is designed to produce the biological therapeutics in the tumors. This prevents drug toxicity and degradation in the bloodstream.

Specific tumor colonization

The inherent feature of bacteria to colonize solid tumors, independent of the genetic profile of the tumor, makes the BacID broadly usable across tumor types, for primary tumors and metastasis.